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Allergic skin disease, is a common occurrence amongst dogs and cats. Yet finding a solution for such patients is often a challenge.
Successful treatment often involves three components:

A combination of therapies to keep itching under control (i.e. a multimodal approach)

Good owner compliance by utilising cost effective and easy to administer products

Good tolerance from the patient ensuring they stay well, over what is often a lifelong issue

So, when presented with allergic skin disease - what do you chose for your patients?

With many different options available, successful protocols are as unique as the patient themselves. When considering the ideal combination of products - Redonyl Ultra provides a helpful addition to your patient’s current regimen, which complements and supports the fight against allergic dermatosis.


 

What is Redonyl Ultra and how can it benefit your patients?

Has there been research to show the efficacy of ultra-micronised PEA?

For further information on research into the use of PEA. Please see the list of additional reading below:

1. Noli C, et al (2015) Efficacy of ultramicronized palmitoylethanolamide in canine atopic dermatitis: an open-label multi-centre study. Veterinary Dermatology 26: 432-e101

2. Scarampella F, Abramo F, Noli C, (2001) Clinical and histological evaluation of an analogue of palmitoylethanolamide, PLR 120 (comicronized Palmidrol INN) in cats with eosinophilic granuloma and eosinophilic plaque: a pilot study. Veterinary Dermatology 12, 29-39

3. Waisglass S. (2012) Palmitoylethanolamide and canine atopic dermatitis: a double-blind, randomized, placebo-controlled clinical trial. Proceedings SkinALIA 2012, Verona, Italy pp 57-61

4. Pistis M, Melis M, (2010) From surface to nuclear receptors: the endocannabinoid family extends its assets. Current Medicinal Chemistry 17(14):1450-67

5. Petrosino S, et al (2018) Oral Ultramicronized Palmitoylethanolamide: Plasma and Tissue Levels and Spinal Anti-hyperalgesic Effect. Frontiers in Pharmacology 20;9:249

6. Impellizzeri D, et al (2014) Micronized/ultramicronized palmitoylethanolamide displays superior oral efficacy compared to nonmicronized palmitoylethanolamide. Journal of Neuroinflammation 11:136

7. Noli C, et al (2018) Ultramicronized palmitoylethanolamide prolongs the effect of a short-course of oral steroids in cats with non-flea hypersensitivity dermatitis and non-seasonal pruritis. A double blind, multicentre, randomised, placebo-controlled study. Veterinary Dermatology 29:368.


Administration

To help with dosing and administration, Redonyl Ultra comes in 50 mg and 150 mg concentrations and is formulated in easy to give skittle capsules. The optimal dose of PEA-um is 10 mg/kg.

When should I give Redonyl Ultra?

Seasonal Cases
In pets with a known seasonal pattern, e.g. animals that itch and develop itch skin lesions as a result of the  pollination season, it is recommended that Redonyl Ultra is administered on an every-other-day schedule (PEA-um 10 mg/kg) at least 30 days prior to the start of allergy season. Then switch to daily administration if relapse occurs.

Non Seasonal Cases
In pets with non-seasonal allergic dermatitis, administer Redonyl Ultra on a daily schedule (PEA-um 10 mg/kg) either as a sole intervention or an add-on intervention according to the severity of disease.


Frequently asked questions

How soon will the skittle dissolve when swallowed whole?

The disintegration time for each skittle is around 8 minutes for the 50 mg skittle and 12 minutes for the 150 mg capsule. In both cases by 4-5 minutes the capsule content starts to leak out from the sealing line.

Can it be used long term?

One of the great benefits of Redonyl Ultra is that it can be used long term in 60 day cycles to be repeated as required. There is a long experience with long-term use in Italy, where the product has been available since 1997.

What is the ideal timeframe to use Redonyl Ultra for?

Redonyl Ultra can be used:

  • During the investigation period, when it is not yet clear what the diagnosis will be. It may take an extended time period until diagnosis can be confirmed, so until this point it is advised to administer the liquid only (i.e. to remove any potential interference from the gelatine capsule).  If undertaking a diet trial as part of the investigative work up, we recommend administering Redonyl Ultra during the first month only, to allow evaluation of the patient during the second month.

    We also recommend stopping Redonyl Ultra two weeks before intradermal skin testing.

  • Before season with an atopic animal (seasonal atopy)
  • In mild to moderate cases: It will not be enough if pruritus is severe (in these cases you might need to add steroids or other systemic treatment for short periods)
  • In atopic animals that are not well controlled.
  • In animals with conditions where standard treatments (glucocorticoids, ciclosporin) are contraindicated. Examples include patients with diabetes, Cushing’s disease, active/progressive tumours or those in immunocompromised states.

Can you combine Redonyl Ultra with a therapeutic diet?

As canine atopic dermatitis is a lifelong condition it is important to have a treatment regimen that works for the individual patient. It is a good idea to feed a diet containing high levels of essential fatty acids and other substances that will improve skin barrier function. However, in some cases a diet may not be enough, therefore it is an excellent idea to include PEA-um into your patients dietary regimen.

I have an animal that is allergic to beef can I still use Redonyl Ultra?

The Redonyl Ultra gelatine capsule contains low levels of protein from beef. If you have an animal that is allergic to beef you can open the capsule and just use the content - pour it on to their food.

 

For more information or to speak to a sales representative please get in touch via our enquiry form

Contact us about Redonyl Ultra


Supporting you

Dechra provides you with an extensive range of resources to support you with diagnosing, treating and monitoring allergic skin disease:

Support Piece

Case Study Report

Best Practice Protocol: Bacterial skin infections

 

Register or log in to access Dechra’s range of
free dermatology educational material

Skin disease accounts for 20% of all consultations in general practice and pruritus represents over 30% of dermatology consultations.1 The primary diseases behind the skin symptoms are diverse. It is therefore important to ensure that you identify the underlying disease and decide on the right treatment. By using Dechra’s range of products, treatment can have a holistic approach in the control and maintenance of dermatological disease.

Find out more about the Range

1. Hill et al (2006) Survey of the prevalence, diagnosis and treatment of dermatological conditions in small animals in general practice. Veterinary Record 158: 533-539

 
 
 
 
 
 
 
 
 
 
 
 
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